Editorial: Coronavirus disease (COVID-19): mechanistic basic, translational, and clinical research aimed at identification of effective preventive and therapeutic strategies
Paolo Montuschi, Fatih Mehmet Uckun, Alastair G. Stewart, Paola Patrignani · Frontiers in Pharmacology · 2023
coronavirus disease (COVID-19), inflammation, cytokine release syndrome, treatments of COVID-19, preventive strategies in Editorial on the Research Topic Coronavirus disease (COVID-19): mechanistic basic, translational, and clinical research aimed at identification of effective preventive and therapeutic strategiesThe coronavirus disease 2019 (COVID-19) is a significant global health concern affecting society and the economy.Although our understanding of the risks associated with COVID-19 has improved, there are still medical challenges to overcome, and effective treatments for severe disease are not yet available.This Research Topic aimed to showcase recent discoveries and ongoing research efforts to help speed up recovery from COVID-19 and prevent life-threatening complications.It comprises four papers.Vukoja et al. reported the experience of the Health Center Grude (Bosnia and Herzegovina) in treating COVID-19 patients.They have shared their expertise, work scheme, therapeutic approach, and management techniques, which have proven beneficial.They presented a case series showing how even severely ill patients can be treated entirely in primary care settings.The management is based on the timely and rational use of dexamethasone and various other pharmacological and nonpharmacological treatments.This approach might be particularly useful when tertiary care centers and academic institutions are overwhelmed.The systemic inflammatory response in critical patients with COVID-19 is associated with alterations in blood lipid profiles.A significant reduction in the levels of apolipoprotein-A-I (ApoA-I), i.e., the major protein component of high-density lipoprotein (HDL), has been detected.This protein has many important functions, such as reducing systemic and lung inflammation, regulating the immune system, and preventing endothelial dysfunction and