Antibacterial investigation of two Benzamide derived compounds against some pathogenic bacteria
Sarwan W. Bradosty, Mohammed Omar Abdullah, Aras Najmaddin Hamad, Nabard Ghafur Ahmed, Fatima Khalid, Shayma Yasin Sabr, Gulala Ismael, Fatima Zuber, Muhammed Mikael · Journal of Survey in Fisheries Sciences · 2023
Antimicrobial drugs have become limited useful against nowadays pathogens; this was because of highly uptake and consumption of previously drugs which leads to gain the resistance potential by Pathogenic microbes generally and bacterial pathogens specifically. So in order to stop the mortality outcomes of these pathogens, we conducted our study to design new hopeful Benzamide derived Antibacterial drugs. in our study we obtained two Benzamide-derived compounds and diluted them in Dimethylsulfoxide (DMSO) at the concentration of (5 and 10mg/ml) and we used Gentamicin(Genta) as positive control, and then we checked them through two standardized antibacterial (Well diffusion and MTT-Microdilution) methods in order to get the IZ and MIC values and evaluate their potential against four common standard bacterial strains which where two gram negative: P. mirabilis (ATCC 14153) and K. pneumonia (ATCC 13883) with two gram positive: E. faecalis (ATCC 29212) and S. pneumoniae (ATCC 6303).in outcomes, our finding showed that both Compound 1 and 2 had only effects on E.faecalis which was (7 and 14mm) of IZ, respectively by only diffusion method. And they didn’t have effects on the rest of bacterial strains. Nevertheless our positive control (Genta) had variable inhibition and killing effect against all bacterial strains.