Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin
Ranit Pariary, Sandip Dolui, Gourav Shome, Sk Abdul Mohid, Achintya Saha, Bhisma Narayan Ratha, Amaravadhi Harikishore, Kuladip Jana, Atin Kumar Mandal, Anirban Bhunia, Nakul C. Maiti · Chemical Communications · 2023
Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting their aggregation. Furthermore, it also increases the insulin secretion. This multipolar effect coupled with its non-toxic nature could be useful for developing highly bioactive, targeted and biostable therapeutic insulin.