Mathematical Modeling of the Biological Activity of a New Complex Compound Based on Palladium and Mexidol
Burak Tüzün, Rana Jafarova, Ismail Bagirov, Nigar Magerramova, Tofa Nasibova · Journal Of Biochemical Technology · 2023
Platinum preparations are widely used in the treatment of cancer patients, as they have an antitumor effect. However, the use of such drugs is limited due to their high toxicity. In this study, the goal was to reveal the anticancer activity of a new complex synthesized compound based on palladium and mexidol (2-ethyl-6-methyl-3-hydroxypyridine ammonium tetrachloropalladic acid), which has low toxicity. The interaction of palladium metal complexes with EGFR kinase protein (PDB ID: 2ITO) and their