Validating a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning
Divya Choudhury, James M. Dolezal, Emma Dyer, Sara E. Kochanny, Siddi Ramesh, Frederick Matthew Howard, Jayson R. Margalus, Amelia R. Schroeder, Jefree J. Schulte, Marina Chiara Garassino, Jakob Nikolas Kather, Alexander T. Pearson · bioRxiv (Cold Spring Harbor Laboratory) · 2023
Abstract Deployment and access to state-of-the-art diagnostic technologies remains a fundamental challenge in providing equitable global cancer care to low-resource settings. The expansion of digital pathology in recent years and its interface with computational biomarkers provides an opportunity to democratize access to personalized medicine. Here we describe a low-cost platform for digital side capture and computational analysis composed of open-source components. The platform provides low-cost ($200) digital image capture from glass slides and is capable of real-time computational image analysis using an open-source deep learning (DL) algorithm and Raspberry Pi ($35) computer. We validate the performance of deep learning models’ performance using images captured from the open-source workstation and show similar model performance when compared against significantly more expensive standard institutional hardware.