Synthesis of SARS-CoV-2 M pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez‐Peña, Stefano Pieraccini, Alessandro Dimasi, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Clelia Giannini, Daniele Passarella · Organic & Biomolecular Chemistry · 2023
A panel of novel cinnamic ester derivatives showed a potent inhibitory effect against SARS-CoV-2 M pro and efficiently impaired the in vitro replication of two human coronaviruses in the low micromolar range.