Stereochemical Structure–Activity Relationship ofN-(2,3-Epoxypropyl)-N-(α-methylbenzyl)benzenesulfonamide Derivatives
Koichi Yoneyama, Nobumasa Ichizen, Makoto Konnai, Tetsuo Takematsu, Kazuyuki Ushinohama, Tetsuo Jikihara · Agricultural and Biological Chemistry · 1984
The absolute configurations of two asymmetric centers in four stereoisomers of N-(2,3-epoxypropyl)-N-(α-methylbenzyl)benzenesulfonamide were determined and their biological activities were tested. Consequently, N-[(R)-2,3-epoxypropyl]-N-[(R)-α-methylbenzyl]benzenesulfonamide was found to be the most active isomer and the stereochemistry of the benzyl position was found to be more important than that of C2 in the epoxypropyl group for biological activity.