Synthesis of bis-furyl-pyrrolo[3,4- b ]pyridin-5-ones via Ugi–Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins
Ivette Morales‐Salazar, Flora P. Montes-Enríquez, Carlos E. Garduño-Albino, Miguel A. García‐Sánchez, Ilich A. Ibarra, Yareli Rojas-Aguirre, Montserrat Elemi García-Hernández, Rosa Elena Sarmiento Silva, Sofía Lizeth Alcaráz‐Estrada, Erik Díaz‐Cervantes, Eduardo González‐Zamora, Alejandro Islas‐Jácome · RSC Medicinal Chemistry · 2022
Six polyheterocycles were studied in vitro against human SARS-CoV-2 finding that one of them exhibited significant activity at initial infection stages, showing prophylactic potential. A second one showed both, prophylactic and therapeutic activity.