Evaluation of Interaction of Some Quinolone Derivatives on RSK-4 Using a Theoretical Model
Rosas‐Nexticapa Marcela, Figueroa‐Valverde Lauro, Magdalena Alvarez-Ramirez, López‐Ramos Maria, Virginia Mateu-Armand, Tomas López-Gutierrez · Clinical Cancer Investigation Journal · 2022
Prostate cancer is one of the leading causes of death among men worldwide; Some data suggest that ribosomal S6 p90 kinase (RSK 1-4), which belongs to the group of highly conserved Ser/Thr kinases, has been related to an increase in prostate cancer levels. For this reason, the aim of this study was to evaluate the theoretical interaction of some quinolone derivatives (compounds 1-19) with RSK-4 using 6rv2 protein and RSK-14 inhibitor (LJH685) in a docking model. The results showed that some quino