Predictive Value Tools as an Aid in Chemopreventive Agent Development
Vernon E. Steele, David F. Ransohoff, Barbara Karen Dunn, Carol F. Topp, Barnett S. Kramer, Richard M. Fagerstrom, Leslie G. Ford, Cunningham, Christopher, Ron Lubet · Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2020
Over 25 years, the National Cancer Institute’s Division of Cancer Prevention has entered some 800 agents into a chemopreventive agent testing program. Two critical steps involve: 1) in vitro/in vivo morphologic assays and 2) animal tumor assays (incidence/multiplicity reduction). We sought to determine how accurately the earlier-stage (morphologic) assays predict efficacy in the later-stage (animal tumor) assays.