Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
Alexander Sedykh, Roustem Saiakhov, Suman Chakravarti, Marlene T. Kim, Hao Zhu · Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2020
Oral bioavailability (%F) is a key factor that determines the fate of a new drug in clinical trials. Traditionally, %F is measured using costly and time -consuming experimental tests. Developing computational models to evaluate the %F of new drugs before they are synthesized would be beneficial in the drug discovery process.