Molecular Docking Study of Canine Olfactory Receptor and Cancer Compounds: Implication in designing of novel biochemical test for detection of cancer
Webology · 2021
Dogs' smell sense has been used by humans in a variety of search operations.It has just lately began to be used to diagnose diseases, including cancer.Dogs can detect volatile organic compounds (VOCs) produced by cancer patients in their breath, urine, saliva, and other bodily fluids and tissues.The researchers looked at the interactions between various VOCs from the VOCC database and mouse receptors from the ODORactor database.iGEMDOCK was also used to investigate the docking of different VOCs and receptors in mice and dogs.Because there was no database of olfactory receptors for dogs, we used the mouse receptor and compared it to the dog olfactory receptor.According to the docking study, one or more VOCs can bind to a specific receptor.A VOC can bind to many receptors at the same time.According to our findings, the amino acid residues LEU-61, 62, 113, 65, and MET-117 are important in a mouse receptor's binding to butyl acetate and 2-methylpropanal.VOCs were discovered to interact with a variety of typical amino acid receptors in dogs and mice.As a result of the in-silico study, an unique technique for cancer diagnosis based on the sense of olfaction of diverse animals has been studied, which will be further validated by laboratory experiments. Conclusions:We also discovered that, in addition to dogs, a variety of other animals can be employed for illness diagnosis, giving a non-invasive method for disease detection and prevention.