Self-supervised deep learning for pan-cancer mutation prediction from histopathology
Oliver Lester Saldanha, Chiara Maria Lavinia Loeffler, Jan Niehues, Marko van Treeck, Tobias Paul Seraphin, Katherine Jane Hewitt, Didem Çifçi, Gregory Patrick Veldhuizen, Siddhi Ramesh, Alexander T. Pearson, Jakob Nikolas Kather · bioRxiv (Cold Spring Harbor Laboratory) · 2022
Abstract The histopathological phenotype of tumors reflects the underlying genetic makeup. Deep learning can predict genetic alterations from tissue morphology, but it is unclear how well these predictions generalize to external datasets. Here, we present a deep learning pipeline based on self-supervised feature extraction which achieves a robust predictability of genetic alterations in two large multicentric datasets of seven tumor types.