Identification of a pyridine derivative of diselenides as a potent inhibitor of the main protease of SARS-CoV-2 through in silico screening and biochemical evaluation
Beena Gobind Singh, Vishwa V. Gandhi, Prasad P. Phadnis, Amit Kunwar · New Journal of Chemistry · 2022
Among the 22 organoselenium compounds studied, 2-Py 2 Se 2 & Nict 2 Se 2 showed the highest affinity for M pro . The biochemical studies confirmed their superiority as compared to standard compound like Ebselen in terms of the IC 50 required for M pro inhibition.