Potential mechanism exploration of San Wei Tan Xiang capsule for depression treatment by network pharmacology and molecular docking
Ruiting Ma, Yuanyuan Ma, Ce Li, Lijun Tong · Medicine in Novel Technology and Devices · 2022
San Wei Tan Xiang (SWTX) capsule has been proved to have significant curative effect on depression in clinic and have less side effects in the treatment. Based on network pharmacology, the mechanism of depression treatment by SWTX capsule was studied. The related targets of depression were collected in the GeneCards database. The active ingredients and potential target genes of SWTX were screened out in the TCMSP database, and the chemical formulas of the active ingredients were confirmed in the PubChem database. As a result, Oleic, quercetin, and beta-sitosterol were screened to be the main ingredients correlated with depression. And NCOA2, GABRA1, and RXRA were analyzed to be the main targets of SWTX on depression. Moreover, the results of molecular docking showed that Oleic and quercetin successfully docked with RXRA. Taken together, using the method of network pharmacology, the main active ingredients of SWTX, and its target points and related pathways on depression are initially revealed, which provides a new idea for depression treatment.