On the Chirality of Drugs and the Structures of Biomacromolecules
Ekaterina Belova, E. V. Semenova, V. A. Tverdislov · BIOPHYSICS · 2022
The development of the concept of the role of chirality in the structural formation of biomacromolecules has been demonstrated using correlations between the chiral form of a drug and its bioactivity. Understanding the nature of the chiral-hierarchical structure of target biomacromolecules and the symmetry structure of drugs is of great importance for establishing the possible systematic character of chiral correspondences between drugs and targets. It is crucial to take the stereoselectivity of drug-target interactions into account when creating drugs because one chiral form of the drug may have a therapeutic effect but the other one may be non-digestible, weakly active, cause severe side effects, or be toxic. The bioactivity of chiral drugs has been discussed, and hypotheses put forward about a possible relationship between drug chirality and the drug effect on a specific chiral molecular target.