Fundamental Limits of Multi-Sample Flow Graph Decomposition
Kayvon Mazooji, Sreeram Kannan, William Stafford Noble, Ilan Shomorony · 2022 IEEE International Symposium on Information Theory (ISIT) · 2022
The problem of decomposing a graph flow into a small set of paths has a wide range of applications, including transcriptome assembly and routing in data networks. A standard formulation is the sparsest flow decomposition problem, which is known to be NP-hard. In this work, we consider a multi-sample variant of this problem, motivated by the problem of identifying and quantifying proteoforms from mass spectrometry data, where multiple views of the graph can be obtained from multiple biological samples. We derive necessary conditions for the set of samples to unambiguously determine the ground truth set of paths, and we design an algorithm with matching sufficient conditions for a large class of problem instances, making our algorithm information optimal for this class of problem instances. The necessary conditions, combined with a probabilistic model for sample generation, yield a characterization of the number of samples needed for unambiguous recovery of the underlying paths. We analyze the algorithm’s performance on flow data simulated on peptide graphs from real mass spectrometry data.