Frontispiece: Water Networks Repopulate Protein–Ligand Interfaces with Temperature
Timothy R. Stachowski, Murugendra S. Vanarotti, J. Seetharaman, Karlo M. Lopez, Marcus M. Fischer · Angewandte Chemie International Edition · 2022
Protein Structures. By collecting matched room-temperature and cryogenic datasets of the biomedical target Hsp90α, Marcus Fischer et al. identified in their Research Article (e202112919) changes in water networks that impact protein conformations at the ligand binding interface.