Evaluation of the hypolipidemic activity of polyherbal formulation through In-vivo and In-silico studies
Shivakumar S. Ladde, Bhusnure O.G. · International Journal of Health Sciences · 2022
Obesity is one of the most important public health issues touching every region of the world. Currently, India is facing the double burden of undernutrition likewise as overnutrition. There are >135 million those that are obese in India. Hyperlipoidaemia is related to risk factors like arteriosclerosis, hypertension, type-II DM, obesity, MI, congestive cardiac failure, angina pectoris, gall bladder diseases, degenerative joint diseases, apnea, and sterility. The present treatment for hyperlipoidaemia is Cholesterol-lowering medications may cause life-threatening serious unwanted effects many facet effects, such as muscle pain, exaggerated glucose levels, constipation, nausea, diarrhea, abdomen pain, cramps, the elevation of liver enzymes. Therefore, the present investigation was designed to investigate the hypolipidemic activity of polyherbal formulation in Wistar rats in an endeavour to determine the traditional use of this Polyherbal formulation and Insilco molecular docking studies. Hypolipidemic effect of polyherbal formulation was studied in the High Cholesterol cocktail diet (HCCD) fed hyperlipidemic rat model and Insilco Molecular docking studies of hHMG Co-A reductase (PBD:1hwk) and analysis of ligand-protein interactions for the prediction of the mechanism of hypolipidemic activity of important phytoconstituents of the polyherbal formulation.