Structure based drug discovery, docking modelling, synthesis and anticonvulsant pharmacological activity of new quinoline derivatives
Honde Bharat Shivaji, Kunkulol Rahul Rajendra · International Journal of Health Sciences · 2022
Novel series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking, modelling and synthesized. The chemical structures of synthesized derivatives were determined by their IR, 1HNMR, MS analysis data, correlate with docking modelling binding affinity and anticonvulsant activity by using mice in MES model. The synthesized derivatives anticonvulsant activity(3-(5-chlorophenyl)-5-phenyl-1H-pyrazol-1-yl) (2-(2-chlorophenyl) quinoline-4yl) methanone(4a) have showed greater as compared to other derivatives according to 25,50 and 100mg/ml concentration as compared to Phenytoin std. drug.