Use of Animals for the Determination of Absorption and Bioavailability
Chris Logan · Methods and principles in medicinal chemistry · 2003
This chapter contains sections titled: Introduction ADME/PK in Drug Discovery The Need for Prediction Consideration of Absorption and Bioavailability Choice of Animal Species Methods Radiolabels Ex vivo Methods for Absorption Static Method Perfusion Methods In vivo Methods In vivo Methods for Determining Bioavailability Cassette Dosing Semi-simultaneous Dosing Hepatic Portal Vein Cannulation Inhalation Relevance of Animal Models Models for Prediction of Absorption Models for Prediction of Volume Prediction of Dose in Man Allometry Physiologically Based Pharmacokinetics Prediction of Human Dose Conclusion