Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study
Zvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheifetz, Irit Ziv, Meir Shoham, Vladimir Vainstein · 2007
This chapter contains sections titled: Introduction Thrombopoiesis Thrombocytopenia Modeling Drug Effects on Thrombopoiesis Using the Validated Model for Predicting Improved Drug Efficacy/Toxicity Profile Using the Thrombopoiesis Model for Predicting an Unknown Animal Toxicity Mechanism Transition to Phase I Conclusion References