Test and reference/control items
OECD · OECD series on testing and assessment · 2018
Key message: The preparation and characterisation of test, reference and control items and their interaction with the in vitro environment should be well understood so as to ensure the acquisition of reliable and relevant results. Key content: Described are test item (characterisation, solubility and handling), test system and test item interaction and biokinetics during development to ensure test item compatibility and correct and reliable exposure.Guidance for improved practice: More detailed information on solubility determination methods; the limitations of test items for which the method is suitable will allow the reader to choose the most suitable approach for his/her particular needs.Recommendations Identify suitable reference and control items to avoid interference of the test, reference and/or control items with the in vitro method