Literature Highlights in Combinatorial Science: QSAR Comb. Sci. 9/2005
QSAR & Combinatorial Science · 2005
Significance: A H-cube apparatus was used in heterogeneous hydrogenation under continuous flow conditions.With dihydropyrimidines obtained from the Biginelli condensation, nitro reduction, benzyl ester deprotection and Raney nickel desulfurization were all demonstrated.Products were prepared in > 100 mg scale in 30 minutes.