DissoCubes—A Novel Formulation for Poorly Soluble and Poorly Bioavailable Drugs
Claudia Jacobs Rainer H. Mu ̈ller · 2002
About 10% of the drugs developed by now are poorly soluble and have bioavailability problems; estimates for the future predict that about 40% of the newly developed drugs will be poorly soluble and subsequently show problems for reaching a therapeutically relevant blood level. Therefore, there is an urgent need to find solutions for the formulation of these poorly soluble drugs. Preferably, such a new formulation principle should be applicable to almost any poorly soluble drug, independent of its chemical structure and spatial molecular dimensions.