Carbon tetrachloride mediated liver fibrosis is alleviated in α7 nicotinic acetylcholine receptor knockout mice
Taiki Mihara, Noriyuki Kaji, Masatoshi Hori · Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2020
Background: Cirrhosis is a condition come from excessive liver fibrosis and followed by serious secondary diseases, but there is no effective therapeutic medicine. α7 nicotinic acetylcholine receptor (α7nAChR), initially found as a receptor related to neurotransmission on neural cells. This receptor also expresses on immune cells to do anti-inflammatory action. However, there is few reports showing the relationship between α7nAChR and fibrosis.