Drug–Target Residence Time
Robert A. Copeland · 2013
This chapter contains sections titled: Key Learning Points Open and Closed Systems in Biology The Static View of Drug–Target Interactions Conformational Adaptation in Drug–Target Interactions Impact of Residence Time on Natural Receptor–Ligand Function Impact of Drug–Target Residence Time on Drug Action Experimental Measures of Drug–Target Residence Time Drug–Target Residence Time Structure–Activity Relationships Recent Applications of the Residence Time Concept Limitations of Drug–Target Residence Time Summary References