Minimizing the Potential for Drug Bioactivation of Drug Candidates to Success in Clinical Development
Ala F. Nassar · 2008
This chapter contains sections titled: Introduction Idiosyncratic Drug Toxicity and Molecular Mechanisms Key Tools and Strategies to Improve Drug Safety Peroxidases Acyl Glucuronidation and S-acyl-CoA Thioesters Covalent Binding Mechanistic Studies Preclinical Development Clinical Development: Strategy Conclusion and Future Possibilities References