Topological Pharmacophores New Methods and Their Application to a Set of Antimalarials Part 2: Results from LOGANA
Rainer Franke, W.J. Streich · Quantitative Structure-Activity Relationships · 1985
Abstract The LOGANA procedure described in part 1 of this series is applied to a set of antimalarials as a test case. Its principle consists in the stepwise combination of binary descriptors characterizing the presence or absence of substructural features into conjunctions using the logical operator “and”, such that the structural patterns described by these conjunctions are typical of the class of high activity compounds. Clear substructural patterns for antimalarial activity are obtained which are consistent with corresponding Hansch equations taken from the literature.