Biological and Environmental Properties of Nitro-, Nitramine- and Nitrate Compounds: Explosives and Drugs—Application of QSPR and QSAR Studies in Environmental Toxicology Assessment
Slobodan Rendić · 2002
Structure-property and structure-activity relationship studies (SPR and SAR, respectively) are important tools in pharmacology, toxicology, environmental research and medicinal chemistry for predicting effects of chemicals on the biological environment. When such effects pertain to additional processes such as metabolism and distribution then these studies are even more important for the deduction, interpretation and generalization of the compounds’ behavior in the environment, since they greatly depend on the structure and physicochemical properties of the chemical(s) in question.1