THE RELATION OF CHOLESTEROL TO THE DEVELOPMENT OF ATHEROSCLEROSIS
P. W. C. · Annals of Internal Medicine · 1950
Editorial1 July 1950THE RELATION OF CHOLESTEROL TO THE DEVELOPMENT OF ATHEROSCLEROSISP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in the relationship of cholesterol to the development of arteriosclerosis dates from the demonstration by Aschoff more than 40 years ago that large amounts of cholesterol and other lipids are present in the atheromatous lesions of the aorta and its larger branches. This interest was greatly intensified by Anitschkow's report (1911) of the experimental production of similar atheromatous lesions in rabbits by feeding cholesterol for long periods. Anitschkow's observations have been abundantly confirmed, and a huge literature has accumulated on this subject.1, 2, 3Although arterial lesions can be produced experimentally by other means, no other procedure has caused...1 Leary T: The genesis of atherosclerosis, Arch. Path. 32: 507-555, 1941. Google Scholar2 Hueper WC: Arteriosclerosis (a general review), Arch. Path. 39: 51 et sq., 1945. Google Scholar3 KatzDauber LNDV: The pathogenesis of arteriosclerosis, J. Mount Sinai Hosp. 12: 382, 1945. Google Scholar4 Winternitz MC: Studies in Pathology of vascular disease, Am. Heart J. 14: 399-404, 1937 CrossrefGoogle Scholar5 HorlickKatz LLN: The relationship of atheromatosis development in the chicken to the amount of cholesterol in the diet, Am. Heart J. 38: 336-349, 1949. CrossrefMedlineGoogle Scholar6 SteinerKendall AFE: Atherosclerosis and arteriosclerosis in dogs following ingestion of cholesterol and thiouracil, Arch. Path. 42: 433-444, 1946. Google Scholar7 SteinerKendallBevans AFEM: Production of arteriosclerosis in dogs by cholesterol and thiouracil feeding, Am. Heart J. 38: 34-42, 1949. CrossrefMedlineGoogle Scholar8 Rabinowitch IM: Arteriosclerosis in diabetes; relationship between plasma cholesterol and arteriosclerosis; effects of high carbohydrate-low caloric diet, Ann. Int. Med. 8: 1436-1474, 1935. LinkGoogle Scholar9 BoasAdlersberg EPD: Familial hypercholesterolemia (xanthomatosis) and atherosclerosis, J. Mount Sinai Hosp. 12: 84-86, 1945. Google Scholar10 BoasParets EPAD: Hereditary disturbance of cholesterol metabolism in the genesis of atherosclerosis, Am. Heart J. 35: 611-622, 1948. CrossrefMedlineGoogle Scholar11 Davis D: Lipid and cholesterol content of the blood of patients with angina pectoris and arteriosclerosis, Ann. Int. Med. 11: 354-369, 1937. LinkGoogle Scholar12 LermanWhite JPD: Metabolic changes in young people with coronary heart disease, (Abst.) Am. Soc. Clin. Invest., May 27, 1946. Google Scholar13 Morrison LM: Cholesterol metabolism: Blood serum cholesterol and ester levels in 200 cases of acute coronary thrombosis, Am. J. M. Sc. 216: 32-38, 1948. CrossrefMedlineGoogle Scholar14 SteinerDomanski AB: Serum cholesterol level in coronary arteriosclerosis, Arch. Int. Med. 71: 397-402, 1943. CrossrefGoogle Scholar15 MorrisonHallGonzales LMLWF: Significance of blood serum cholesterol instability in coronary arteriosclerosis, (Abst.) Am. Heart J. 38: 478, 1949. Google Scholar16 SteinerTurner AKB: Observations on the serum cholesterol in acute infections as recorded during and after pneumonia, J. Clin. Invest. 19: 373-377, 1940. CrossrefMedlineGoogle Scholar17 Rosenthal SR: Studies in atherosclerosis: chemical, experimental and morphologic; etc., Arch. Path. 18: 473, 660, 827, 1934. Google Scholar18 TurnerSteiner KBA: A long term study of the variation of the serum cholesterol in man, J. Clin. Invest. 18: 45-50, 1939. CrossrefMedlineGoogle Scholar19 SteinerDomanski AB: Dietary hypercholesterolemia, Am. J. M. Sc. 201: 820-S24, 1941. CrossrefGoogle Scholar20 Feinblatt HM: Fat metabolism, Am. J. Digest. Dis. 11: 260-261, 1944. CrossrefGoogle Scholar21 Moreton JR: Physical state of lipids and foreign substances producing atherosclerosis, Science 107: 371-373, 1948. CrossrefMedlineGoogle Scholar22 Morrison LM: Fat tolerance tests in coronary thrombosis, (Abst.) Am. Heart J. 38: 477, 1949. Google Scholar23 ThannhauserMagendantz SJH: Different clinical groups of xanthomatous diseases; clinical physiological study of 22 cases, Ann. Int. Med. 11: 1662-1746, 1938. LinkGoogle Scholar24 Kempner W: Treatment of hypertensive vascular disease with rice diet, Am. J. Med. 4: 545-577, 1948. CrossrefMedlineGoogle Scholar25 HorlickKatzStamler LLNJ: The effect of a low fat diet on the spontaneously occurring arteriosclerosis of the chicken, Am. Heart J. 37: 689-700, 1949. CrossrefMedlineGoogle Scholar26 Stamler J: Studies on spontaneous and cholesterol-induced atherosclerosis and lipid metabolism in the chick. The effect of some lipotropic and hormonal factors, (Abst.) Am. Heart J. 38: 466, 1949. Google Scholar27 Page IH: Some aspects of the nature of the chemical changes occurring in atheromatosis, Ann. Int. Med. 14: 1741-1755, 1941. LinkGoogle Scholar28 Brown GO: Studies of the effect of lipotropic agents in experimental cholesterol atherosclerosis in the rabbit, (Abst.) Am. Heart J. 35: 862, 1948. CrossrefMedlineGoogle Scholar29 Steiner A: Effect of choline in the prevention of experimental aortic atherosclerosis, Arch. Path. 45: 327, 1948. Google Scholar30 MorrisonGonzales LMWF: Results of treatment of coronary arteriosclerosis with choline, (Abst.) Am. Heart J. 38: 471, 1949. Google Scholar31 AdlersbergSobotka DHJ: Effect of prolonged lecithin feeding on hypercholesteremia, J. Mount Sinai Hosp. 9: 955-956, 1943. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE VALUE OF DETERMINATIONS OF CHOLESTEROL AND OF LIPOPROTEINS OF LOW DENSITY IN THE BLOOD AS PREDICTORS OF OVERT ATHEROSCLEROSISRECENT HISTORY OF CORONARY DISEASE 1 July 1950Volume 33, Issue 1Page: 250-258KeywordsAortaAtherosclerosisCholesterolLesionsLipidsRabbits ePublished: 1 December 2008 Issue Published: 1 July 1950 PDF downloadLoading ...