Automated Cytochemistry in Acute Leukemia
Giuseppe d’Onofrio, Giorgio Mango · Acta Haematologica · 2009
Automated Cytochemistry in Acute LeukemiaWe wish to make several remarks about the paper by Cranendonk et ah: Evaluation of the use of the Hemalog D in acute lymphoblastic leukemia and dis seminated non-Hodgkin's lymphoma in children [Acta haemat.71: 18-24 (1984)], which deals with automated cytochemistry performances in acute leu kemias.The subject, indeed, is not a worthless one: automated leukocyte differential devices, in fact, are more and more diffused among hematology labora tories, so that the awareness of their qualities and de fects deserves considerable interest.In that paper, the authors report their results con cerning Hemalog D differential counts in 79 children with acute lymphoblastic leukemia (ALL) and 18 children with disseminated non-Hodgkin's lympho ma; only 25 of them, however, were studied since the onset of their disease.The authors generalize their conclusions, claiming that the Hemalog D seems inadequate in diagnosis and follow-up of leukemic patients.Over the last 4 years we have been able to analyze a large number of leukemic blood samples with the Hemalog D [1, 3].We would like to report very briefly our experience, which is indeed quite different.