Physicochemistry
Dennis A. Smith, H. Van De Waterbeemd, Don K. Walker · Methods and principles in medicinal chemistry · 2001
Physicochemistry and pharmacokinetics Partition and distribution coefficient as measures of lipophilicity Limitations in the use of 1-Octanol Further understanding of log P Unravelling the principal contributions to log P Hydrogen bonding Molecular size and shape Alternative lipophilicity scales Computational approaches to lipophilicity Membrane systems to study drug behaviour