Translation Initiation Abnormality
National Cancer Institute · Definitions · 2020
An abnormality that results from a functional change in the mRNA sequence at the translation initiation codon.In eukaryotic organisms, the initiation codon is always AUG.A mutation in either DNA or corresponding mRNA that alters this initiation sequence causes termination of mRNA translation.No functional protein product is synthesized when a translation initiation abnormality exists.