Effect of Acetaminophen on Atherosclerosis
Pang H Chong, Bob Kezele, Pamala J Pontikes · Annals of Pharmacotherapy · 2001
OBJECTIVE:To evaluate the antioxidant effects of acetaminophen in atherosclerosis.DATA SOURCES:Experimental literature and abstracts accessed through MEDLINE (1966–February 2001).DATA SYNTHESIS:Atherosclerosis is an inflammatory disorder associated with coronary events. The oxidative stress burden resulting from excess pro-oxidant free radical formation contributes to oxidative modification of low-density lipoprotein (lipid peroxidation) and is associated with atherosclerosis. Acetaminophen (phenol-like compound) may limit these key processes that are involved. The findings of earlier experimental laboratory tests and abstracts are evaluated.CONCLUSIONS:In vitro data suggest that acetaminophen may reduce lipid peroxidation, whereas animal data showed decreased progression of atherosclerosis. Further animal model and human studies are required to confirm these earlier findings.