Toxicity
Dennis A. Smith, H. Van De Waterbeemd, Don K. Walker · Methods and principles in medicinal chemistry · 2001
Toxicity findings Pharmacophore-induced toxicity Structure-related toxicity Metabolism-induced toxicity Epoxides Quinone imines Nitrenium ions Imminium ions Hydroxylamines Thiophene rings Thioureas Chloroquinolines Stratification of toxicity Toxicity prediction - computational toxicology Toxicogenomics Enzyme induction (CYP3A4) and drug design