Statistical Methods in Translational Medicine
Shein‐Chung Chow, Jen‐pei Liu · Wiley series in probability and statistics · 2013
This chapter focuses on statistical methods for translation in information and translation in technology. Translation medicine is divided into discovery translational medicine and clinical translational medicine. The chapter outlines statistical method for optimal variable screening in microarray analysis. Also included here is the cross-validation method for model selection and validation. The chapter discusses statistical methods for assessment of oneway/ two-way translation and lost in translation in the bench-to-bedside translational process in pharmaceutical development. Whether or not an established animal model is predictive of a human model is examined. The chapter studies the relationships among different study endpoints, which are derived from data collected from the same target patient population. It describes Issues that are commonly encountered in translation in technology. The generalization of results obtained from a target patient population to another similar but different target patient population is also discussed in this chapter. Controlled Vocabulary Terms statistical measures