CliP: A model-based method for subclonal architecture reconstruction using regularized maximum likelihood estimation
Wenyi Wang, Yujie Jiang · 2020
Authors: Yujie Jiang, Kaixian Yu, Marek Kimmel, Scott Kopetz, Hongtu Zhu Affiliations: MD Anderson Cancer Center, Rice University, UNC Chapel Hill Abstract Body: "Background Subpopulations of tumor cells characterized by mutation profiles may confer differential fitness to treatment and prognosis across cancers. Understanding subclonal architecture has the potential