Stoichiometric and Constraint-based Modeling
Steffen Klamt, Jörg Stelling · The MIT Press eBooks · 2006
This chapter explains the main concepts of stoichiometric network analysis (SNA). Stoichiometric modeling has become an important approach for understanding the function of metabolic networks. Hence, the focus is on metabolism, and extensions to cellular regulation are discussed. One aim of the chapter is to review critically virtues and limitations of the approaches with respect to their potential applications for realistic biological networks. It compares four major approaches to SNA by addressing the following issues: network consistency, functional pathways and cycles, network capabilities, importance of reactions, correlated reactions, network design, and network flexibility and robustness.