Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes
Chi Xu, Daosheng Ai, Dawei Shi, Shengbao Suo, Xingwei Chen, Yizhen Yan, Yaqiang Cao, Rui Zhang, Na Sun, Weizhong Chen, Joseph McDermott, Shiqiang Zhang, Yingying Zeng, Jing‐Dong J. Han · Cell Reports · 2019
(Cell Reports 25, 523–535.e1–e5; October 9, 2018) In the originally published version of this article, Dawei Shi ([email protected]) and Rui Zhang ([email protected]) were mistakenly omitted from the author list. The corrected author list appears here and with the paper online. The authors regret this error. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer TranscriptomesXu et al.Cell ReportsOctober 09, 2018In BriefXu et al. generated core transcriptome signatures representing single-gene mutations for 8,476 human genes from the cancer transcriptomes in the TCGA database and developed a drug-repositioning method to predict high-specificity candidate target genes for 1,938 drugs. Applied to targeting aging pathways, 7 lifespan-extending drugs are found and functionally validated. Full-Text PDF Open Access