Novel adamantyl clubbed iminothiazolidinones as promising elastase inhibitors: design, synthesis, molecular docking, ADMET and DFT studies
Atteeque Ahmed, Aamer Saeed, Syeda Abida Ejaz, Mubashir Aziz, Muhammad Zaffar Hashmi, Pervaiz Ali Channar, Qamar Abbas, Hussain Raza, Zahid Shafiq, Hesham R. El‐Seedi · RSC Advances · 2022
Structurally diverse adamantyl-iminothiazolidinone conjugates were synthesized, evaluated for elastase inhibition, and subjected to in silico ADMET prediction. The inhibition studies revealed compounds 5a, 5f, 5g, and 5h to show significant activity.