Based on network pharmacology and molecular docking technology, to explore the molecular mechanism of Sedum sarmentosum affecting atherosclerosis by interfering with MMP-2 related signal pathway
Zhe Liu, Qintong Yang, Yudong Fang · Research Square · 2022
Abstract By matching 333 Sedum sarmentosum targets with 2072 atheromatosis targets, 175 overlapping targets were screened, and MMP-2 was determined as one of the core targets. Gene functions are mainly involved in lipid metabolism, energy pathways, signal transduction, and so on. PI3K-Akt signaling pathway, Ras signaling pathway, Arachidonic acid metabolism, Rap1 signaling pathway, etc. may be the key pathways for Sedum sarmentosum treatment of atheromatosis. Sedum sarmentosum has great potential to be developed as a drug and targets various genes and pathways to play a role in the treatment of atheromatosis.