Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates
Ana Paula Araujo de Oliveira, Victoria C. Romero Colmenares, Renata Diniz, Jennifer Tavares Jacon Freitas, Clara M. da Cruz, Eduardo Burgarelli Lages, Lucas Antônio Miranda Ferreira, Rafael Pinto Vieira, Heloísa de Oliveira Beraldo · ACS Omega · 2022
might be an effective strategy to obtain a prodrug candidate with increased lipophilicity, which would be able to passively cross biological barriers during transdermal delivery and might have applications in the treatment of Alzheimer's disease and other neurological disorders.