Tooth Decay Fighter Goes Distance
Chemical & Engineering News · 1954
NEW YORK.—Radioisotope research is giving new and direct evidence of the enzyme blocking action of sodium η-lauroyl sarcosinate, says Colgate-Palmolive. Toothpastes containing sarcosinate (trade-named Gardol) synthesized with radioactive carbon were brushed on the teeth of laboratory animals. Although the animals' mouths were rinsed immediately, radioactivity showed that the inhibitor was still present after 48 hours. Colgate has now been issued a patent (USP 2,689,170) covering toothpastes and similar preparations containing sodium η-lauroyl sarcosinate. Big problem in controlling tooth decay through type of dental hygiene used by the great majority of Americans is to find an agent that will remain effective throughout the period between the usual morning and evening brushing. For years, dentists have been advocating cleaning the teeth immediately after every meal. This is impossible for many people, who are away from home for most of their day. Inhibition of the enzyme system which converts sugars to tooth-pitting acids seems to offer a promising ...