Chemical Constituents of Artemisia Annua are Potent Inhibitors of Alpha-Amylase in Type II Diabetes
Erum Dilshad, Farkhanda Mehmood, Rida Tariq, Anum Munir, Sahar Fazal · Life and Science · 2021
Objective: To identify the inhibitory effects of artemisinin and its derivatives against Alpha-Amylase in DiabetesII.Study Design: Insilico approaches using Bioinformatics techniques were used to access the effects of arteisininand its derivatives.Place and Duration of Study: The study was conducted comprising 6 month period at Capital University ofScience and Technology, Islamabad, Pakistan.Materials and Methods: In this work, the inhibitory effects of artemisinin and its derivatives were determinedby using in silico approach. For proper inhibitory effects, molecular docking and the pharmacokineticproperties of the ligand were identified.Results: Artemether was found to be the ligand that shows the best binding energy -7.08 Kcal/mol, stronghydrogen bonding, 4 alkyl bonds, 0 bumps, inhibition constant 13.26, and better pharmacokinetic properties. Ithas been selected as a lead compound as it is the most active compound for alpha-amylase inhibition.Conclusion: In future, this work can be used in wet-lab analysis to confirm its adequacy and efficacy.