Absolute bioavailability of a substance with cardioprotective activity (ALM-802) in rats
Геннадий Борисович Колыванов, Павел Олегович Бочков, Александр Алексеевич Литвин, Роман Владимирович Шевченко, Анна Леонидовна Подолько, Владимир Павлович Жердев · Pharmacokinetics and Pharmacodynamics · 2022
The pharmacokinetics of a new potential cardioprotective agent ALM-802 was studied in rats after single intravenous and intragastric administration at doses of 10 and 100 mg/kg, respectively. The absolute bioavailability was 4.45 %, which indicates the potential for the development of a dosage form for oral administration