Pharmacogenomics and Drug Design
Philip Dean, Paul J. Gane, Edward D. Zanders · Pharmacogenomics · 2002
This chapter contains sections titled: Introduction The Need for Protein Structure Information Protein Structure and Variation in Drug Targets – the Scale of the Problem Mutations in Drug Targets Leading to Changes in the Ligand Binding Pocket β2-Adrenergic Receptor STI-571 and BCR-ABL Resistance to Human Immunodeficiency Virus (HIV) In silico Design of Small Molecules Automated Drug Design Methods Structure-Based Drug Design Ligand-Based Drug Design Future Directions