The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid
Anna Cebrián-Prats, Alexandre V. Pinto, Àngels González‐Lafont, Pedro Alexandrino Fernandes, José M. Lluch · Organic & Biomolecular Chemistry · 2022
Aspirin-acetylated COX-2, but not COX-2, triggers the biosynthesis of anti-inflammatory E-series resolvins. The role of aspirin in the molecular mechanism of resolvin formation from EPA is revealed by MD simulations and QM/MM calculations.