Automated high-throughput registration for localizing 3D mouse brain gene expression using ITK
Lydia Ng, Michael Hawrylycz, David R. Haynor · The Insight Journal · 2005
The Allen Brain Atlas (ABA) project aims to create a cellular-resolution, genome-wide map of gene expression in the adult mouse brain. The resulting in situ hybridization (ISH) image data will be available free-of-charge to the public. Additionally, we are developing an informatics pipeline to support searching of the data by anatomic region and expression level and/or pattern. This paper describes a robust, high-throughput registration scheme to automatically annotate hierarchical brain structures in the ISH imagery.