Multiscale modeling and simulation of drug release from cardiovascular stents
Christian Vergara, Paolo Zunino · Aisberg (University of Bergamo) · 2008
In this study, we focus on a specific application, the modeling and simulation of drug release from cardiovascular drug eluting stents. In particular, we analyze the drug release dynamics from the stent coating, where the drug is initially stored, to the surrounding arterial wall. The main challenge consists in accounting for multiple space scales. To this purpose, we derive suitable boundary conditions accounting for the smaller scales on the macroscopic model. This approach, applied to drug delivery, significantly cuts down the computational cost of the numerical simulations and allows us to consider a realistic problem setting.